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In post-menopausal women, breast cancer risk is around twice as high in those with the highest sex hormone levels (including oestradiol, oestriol, androstenedione and testosterone) compared with the lowest, a pooled analysis of cohort studies showed.[1] In pre-menopausal women, breast cancer risk is not significantly associated with oestrogen levels, a meta-analysis and the EPIC cohort study have shown.[1,2] Pre-menopausal breast cancer risk is 56% higher in those with the highest serum testosterone levels compared with the lowest, whilst other sex hormones show no clear association, EPIC showed.[2] Some reproductive factors modify sex hormone levels; reduction in overall oestrogen exposure may partly explain the link between reproductive factors and breast cancer risk.

Breastfeeding is classified by the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) as probably protective against breast cancer.[1] Breast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed.[1] The association may be limited to ER/PR-positive tumours.[2-4] ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed.[4] HER2-positive and triple-negative breast cancers are not associated with age at first birth.[4] Conversely among BRCA1 mutation carriers, breast cancer risk may be lower in those who are older at first birth, meta-analyses have shown;[5,6] among BRCA2 carriers, breast cancer risk is not associated with age at first birth.[5,6] Breast cancer risk increases by 5% for each year younger at menarche (first menstrual period), a meta-analysis has shown.[1] The association is stronger for oestrogen receptor (ER)-positive and progesterone receptor (PR)-positive tumours than for ER- and PR-negative tumours.[2] Breast cancer risk may be higher in women whose breast development started at a younger age, a cohort study indicates.[3] Among BRCA1 mutation carriers too, breast cancer risk may be higher in those who are younger at menarche, a meta-analysis showed; among BRCA2 carriers, breast cancer risk is not associated with age at menarche.[4,5] Breast cancer risk increases by around 3% for each year older at menopause, a meta-analysis has shown.[1] Post-menopausal women (natural menopause or induced by surgery) have a lower risk of breast cancer than pre-menopausal women of the same age and childbearing pattern, a meta-analysis showed.[1] Breast cancer risk is not associated with tubal sterilisation, a meta-analysis showed.[1] Breast cancer risk is 24-41% lower in women who have hysterectomy and oophorectomy before menopause, compared with women who do not have these surgeries, a pooled analysis and case-control study showed.[2,3] Hysterectomy and oophorectomy after menopause may be associated with increased breast cancer risk if oestrogen therapy is used after the surgery, a pooled analysis showed.[2] Current or recent use of combined oestrogen-progestogen oral contraceptives (OCs) is classified by the International Agency for Research on Cancer (IARC) as a cause of breast cancer.[1] An estimated 1% of female breast cancers in the UK are linked to OCs; because breast cancer risk is generally low in the OC-using population (typically younger women), OC-related risk contributes a relatively small number of additional cases.[2] OCs contain synthetic sex hormones, which may explain the link between OC use and breast cancer risk.

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Breast cancer risk is 55-100% higher in oestrogen-progestogen HRT (combined HRT) current users versus never users, cohort studies have shown.[3,4] Breast cancer risk is also higher in oestrogen-only HRT users, though to a lesser extent than with combined HRT, cohort studies have shown.[3,5-9] Breast cancer risk is not associated with past HRT use 5 years or longer ago, cohort studies have shown.[3,10] Breast cancer risk among current HRT users increases with duration of use, and with lower body mass index (BMI).[3,10,5-9] Breast cancer risk among HRT users may vary with previous use of OCs, but evidence remains unclear.[11-13] Breast cancer risk does not appear to be increased by use of phytoestrogens (plant-derived chemicals used by some women as an alternative to HRT), a meta-analysis showed;[14] however the efficacy of phytoestrogens for relieving menopausal symptoms remains unclear.[15] Hereditary factors explain only around a quarter of breast cancer risk.[1] Breast cancer risk is not associated with breast cancer in an adoptive parent, and does not vary with time since the family member was diagnosed, indicating genetic/biological factors or increased diagnostic activity rather than environmental factors underpin familial clustering of breast cancer cases.[2,3] Breast cancer risk is around twice higher in women with one first-degree relative with breast cancer, versus women with no first-degree relatives with the disease, meta- and pooled-analyses have shown.[1,2] The risk is higher still with a larger number of affected first-degree relatives, or relatives affected aged under 50.[1,2] ER-positive or ER-negative breast cancer risk are associated to a similar extent with family history.[3] Over 85% of women with a first-degree relative with breast cancer will never develop breast cancer themselves.[1] 87% of women with breast cancer have no first-degree relatives with the disease.[1] BRCA1 and BRCA2 mutations confer a high risk of breast cancer in carriers (high-penetrance).

Women with a BRCA1 or BRCA2 mutation have a 45-65% chance of developing breast cancer by age 70.[1] BRCA1/2 mutation-carriers have higher breast cancer risk compared with the general population in all age groups.[1] BRCA2-negative women with a BRCA2-carrying first-degree relative may also have increased breast cancer risk, a small UK cohort study showed.[2] Higher sex hormone levels in BRCA mutation carriers may explain some of the increased risk.[3] Breast cancer risk in BRCA mutation carriers may be modified by other factors including family history (breast cancer risk among BRCA2 mutation carriers is 70% higher for each first-degree relative with breast cancer aged 50 or younger, versus BRCA2 mutation carriers with no such family history; breast cancer risk in BRCA1 mutation carriers is not associated with family history),[4] previous breast cancer,[5] and lifestyle factors (indicated by higher risk in BRCA mutation carriers born post-1950 versus pre-1950[6]).

Tout comme Alexandre Aja qui a réalisé six films d’horreur, Daniel Radcliffe semble être lui aussi adepte de ce genre cinématographique et ses variantes, puisqu'il a joué en 2012 dans La Dame en noir et sera à l'affiche de Victor Frankenstein.

Soupçonné d’avoir assassiné sa fiancée, rejeté par tous ceux qu’il connaît, Ignatius a sombré dans le désespoir.

Un matin, il se réveille avec une paire de cornes sur la tête.

Horns est une adaptation du roman du même nom paru en 2010 et signé par Joe Hill, qui n'est autre que le fils de Stephen King : "Le mélange de ton de cette allégorie de l’Amérique moderne m’a frappé par sa nouveauté.

J’ai été ému par l’histoire d’amour, séduit par la satire et amusé par ce portrait absurde et un brin morbide de la nature humaine.

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