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For women with intrinsic sphincteric dysfunction, estrogen therapy, alpha agonists, or both have provided some improvement in symptoms.

Periurethral collagen injections are most effective for women with intrinsic sphincteric dysfunction, producing cure rates that last as long as 1 or 2 years.

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Overall improvement varies from 35-70%, and multiple injections are often required.

Nonetheless, collagen injections present a less-invasive alternative for patients who are wary of an implanted device or are poor candidates for the artificial urinary sphincter.

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